Cflar - CASP8 and FADD-like apoptosis regulator

Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of programmed cell death and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]