Cfl2 - cofilin 2, muscle

Enables actin filament binding activity. Involved in actin filament fragmentation and skeletal muscle tissue development. Acts upstream of or within actin filament organization; muscle cell cellular homeostasis; and sarcomere organization. Predicted to be located in Z disc. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in heart ventricle; limb musculature; myotome; and neural retinal epithelium. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Apr 2022]