Cdc42 - cell division cycle 42

Enables several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to interferon-gamma; filopodium assembly; and positive regulation of phosphatidylinositol 3-kinase activity. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]