Rb1cc1 - RB1-inducible coiled-coil 1

Enables protein kinase binding activity. Involved in autophagosome assembly. Acts upstream of or within several processes, including positive regulation of cell size; regulation of signal transduction; and reticulophagy. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including heart; musculoskeletal system; nervous system; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]