Casp14 - caspase 14

Predicted to enable cysteine-type endopeptidase activity involved in execution phase of apoptosis. Predicted to be involved in cornification. Predicted to act upstream of or within cell differentiation and proteolysis. Predicted to be located in several cellular components, including keratin filament; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in embryo; epidermis; epidermis stratum corneum; and skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis. Orthologous to human CASP14 (caspase 14). [provided by Alliance of Genome Resources, Apr 2022]