Enables calmodulin-dependent protein kinase activity. Involved in regulation of neuron migration. Acts upstream of or within several processes, including activation of meiosis involved in egg activation; modulation of chemical synaptic transmission; and protein phosphorylation. Located in cytosol; postsynaptic density; and spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeletal musculature. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 54. Orthologous to human CAMK2B (calcium/calmodulin dependent protein kinase II beta). [provided by Alliance of Genome Resources, Apr 2022]