Anxa2 - annexin A2

Predicted to enable several functions, including enzyme binding activity; enzyme inhibitor activity; and phospholipid binding activity. Involved in several processes, including negative regulation of low-density lipoprotein particle receptor catabolic process; positive regulation of low-density lipoprotein particle clearance; and positive regulation of low-density lipoprotein particle receptor binding activity. Acts upstream of or within several processes, including angiogenesis; collagen fibril organization; and fibrinolysis. Located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and myelin sheath adaxonal region. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; dorsal aorta; oral epithelium; primary palate; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]