Enables protein domain specific binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nuclear envelope lumen. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; liver lobe; nervous system; and sensory organ. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Apr 2022]