Cacnb4 - calcium channel, voltage-dependent, beta 4 subunit

Enables voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including adult walking behavior; cellular response to leukemia inhibitory factor; and hematopoietic or lymphoid organ development. Located in glutamatergic synapse. Part of voltage-gated calcium channel complex. Is expressed in cerebellum; heart; and telencephalon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]