Cacna1c - calcium channel, voltage-dependent, L type, alpha 1C subunit

Enables enzyme binding activity; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of adenylate cyclase activity. Acts upstream of or within several processes, including adult walking behavior; regulation of blood circulation; and secretion by cell. Located in several cellular components, including T-tubule; Z disc; and dendritic shaft. Part of caveolar macromolecular signaling complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and heart. Used to study Timothy syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]