Cacna1a - calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Enables high voltage-gated calcium channel activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Acts upstream of or within several processes, including cellular ion homeostasis; chemical synaptic transmission; and nervous system development. Located in dendrite and neuronal cell body. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]