Bmi1 - Bmi1 polycomb ring finger oncogene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; histone modification; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PcG protein complex and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]