Blk - B lymphoid kinase

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of leukocyte apoptotic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including 2-cell stage embryo; central nervous system; ileum; male reproductive gland or organ; and peripheral nervous system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]