Bid - BH3 interacting domain death agonist

Enables ubiquitin protein ligase binding activity. Involved in positive regulation of cellular component organization; protein-containing complex assembly; and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; hepatocyte apoptotic process; and regulation of apoptotic process. Located in cytosol; membrane; and mitochondrion. Is integral component of mitochondrial membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Apr 2022]