Bcl10 - B cell leukemia/lymphoma 10

Enables CARD domain binding activity and identical protein binding activity. Involved in antifungal innate immune response; neural tube closure; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in MALT lymphoma; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Apr 2022]