Bach2 - BTB and CNC homology, basic leucine zipper transcription factor 2

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Apr 2022]