Axin2 - axin 2

Enables I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]