Atp2a2 - ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Enables several functions, including P-type calcium transporter activity; calcium ion binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]