Arc - activity regulated cytoskeletal-associated protein

Predicted to enable mRNA binding activity. Involved in long-term memory; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic plasticity. Acts upstream of or within anterior/posterior pattern specification and endoderm development. Located in several cellular components, including dendritic spine; glutamatergic synapse; and neuronal ribonucleoprotein granule. Is expressed in several structures, including central nervous system; extraembryonic component; metanephros; pancreas mesenchyme; and retina. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Apr 2022]