Birc2 - baculoviral IAP repeat-containing 2

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in necroptotic process. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in brain ventricular layer; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]