Apex1 - apurinic/apyrimidinic endonuclease 1

Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]