Tbp - TATA box binding protein

Enables DNA binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of transcription, DNA-templated and spermatogenesis. Located in nucleus. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Apr 2022]