Csrp3 - cysteine and glycine rich protein 3

Enables MRF binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in blood vessel remodeling. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of myotube differentiation. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]