Slc25a4 - solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Enables ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including adenine nucleotide transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]