Rhoa - ras homolog family member A

Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of cellular protein metabolic process; and regulation of neuron projection development. Acts upstream of or within negative regulation of vascular associated smooth muscle cell migration and negative regulation of vascular associated smooth muscle cell proliferation. Located in axon; cytosol; and membrane. Used to study membranous glomerulonephritis. Biomarker of asthma; fetal alcohol syndrome; hypertension; obesity; and pulmonary hypertension. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]