Eif2b4 - eukaryotic translation initiation factor 2B subunit delta

Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; negative regulation of guanyl-nucleotide exchange factor activity; and response to glucose. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Apr 2022]