Alx4 - aristaless-like homeobox 4

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; embryonic skeletal system morphogenesis; and roof of mouth development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and sensory organ. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]