Cdk5r1 - cyclin-dependent kinase 5 regulatory subunit 1

Enables several functions, including cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and ephrin receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; nervous system development; and regulation of synaptic vesicle cycle. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Part of protein kinase 5 complex. Is active in presynapse. Biomarker of hypothyroidism and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]