Cacnb2 - calcium voltage-gated channel auxiliary subunit beta 2

Enables several functions, including actin filament binding activity; calcium channel regulator activity; and identical protein binding activity. Contributes to voltage-gated calcium channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated calcium channel activity; and protein localization to plasma membrane. Part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]