Enables peptide hormone binding activity. Involved in cGMP-mediated signaling and positive regulation of cGMP-mediated signaling. Located in plasma membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]