Plod1 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Enables several functions, including L-ascorbic acid binding activity; ferrous iron binding activity; and procollagen-lysine 5-dioxygenase activity. Involved in cellular response to hormone stimulus; peptidyl-lysine hydroxylation; and response to hypoxia. Predicted to be located in rough endoplasmic reticulum membrane. Predicted to be part of catalytic complex. Predicted to be active in endoplasmic reticulum. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]