Ncoa6 - nuclear receptor coactivator 6

Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]