Enables adenylate kinase activity. Acts upstream of or within regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm; outer dense fiber; and plasma membrane. Is expressed in several structures, including heart; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]