Agtr2 - angiotensin II receptor, type 2

Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; metanephros development; and positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]