Agtr1a - angiotensin II receptor, type 1a

Enables angiotensin type I receptor activity. Involved in multicellular organism aging; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; negative regulation of smooth muscle cell apoptotic process; and regulation of blood pressure. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; genitourinary system; and submandibular gland. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]