Agrn - agrin

Enables several functions, including chondroitin sulfate binding activity; heparan sulfate proteoglycan binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of sodium ion transmembrane transport; positive regulation of protein modification process; and positive regulation of synaptic assembly at neuromuscular junction. Acts upstream of or within several processes, including neurotransmitter receptor metabolic process; positive regulation of neuron apoptotic process; and regulation of synaptic assembly at neuromuscular junction. Located in several cellular components, including basement membrane; sarcolemma; and synaptic cleft. Is expressed in several structures, including lower jaw; metanephros; musculature; nervous system; and retina. Used to study congenital myasthenic syndrome 8. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Apr 2022]