Enables protein C-terminus binding activity. Involved in response to organic substance. Located in bicellular tight junction. Biomarker of hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Apr 2022]