Plcz1 - phospholipase C, zeta 1

Enables phosphatidylinositol phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Acts upstream of or within calcium ion transport and egg activation. Located in nucleolus; nucleoplasm; and pronucleus. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1). [provided by Alliance of Genome Resources, Apr 2022]