Dusp1 - dual specificity phosphatase 1

Enables growth factor binding activity and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and response to testosterone. Located in nucleus. Used to study Huntington's disease. Biomarker of autoimmune disease (multiple); brain disease (multiple); hypertension; pancreatitis; and portal hypertension. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]