Pawr - PRKC, apoptosis, WT1, regulator

Predicted to enable actin binding activity; enzyme binding activity; and leucine zipper domain binding activity. Involved in negative regulation of fibroblast proliferation; regulation of cellular response to stress; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of lymphocyte proliferation; and positive regulation of amyloid precursor protein biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAWR (pro-apoptotic WT1 regulator). [provided by Alliance of Genome Resources, Apr 2022]