Plce1 - phospholipase C, epsilon 1

Enables phosphatidylinositol phospholipase C activity and small GTPase binding activity. Involved in G protein-coupled receptor signaling pathway and Ras protein signal transduction. Located in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]