Tle6 - transducin-like enhancer of split 6

Predicted to enable transcription corepressor activity. Involved in several processes, including cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in several structures, including brain; early conceptus; foregut-midgut junction; gonad; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in infertility. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]