Ryr1 - ryanodine receptor 1

Enables ryanodine-sensitive calcium-release channel activity. Involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to estradiol; and response to purine-containing compound. Located in sarcolemma; sarcoplasmic reticulum membrane; and terminal cisterna. Is extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in central core disease; malignant hyperthermia; and multiminicore disease. Orthologous to human RYR1 (ryanodine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]