Enables Notch binding activity. Involved in central nervous system development; negative regulation of Notch signaling pathway; and regulation of neurogenesis. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Apr 2022]