P2rx2 - purinergic receptor P2X 2

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Is integral component of membrane. Part of receptor complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]