Enables serine-type peptidase activity. Involved in proteolysis. Located in basolateral plasma membrane and extracellular space. Is extrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Apr 2022]