Abl2 - v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in actin cytoskeleton organization; peptidyl-tyrosine phosphorylation; and synapse maturation. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse. Is expressed in several structures, including brain; diaphragm; hindlimb long bone; liver; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]