Egln1 - egl-9 family hypoxia-inducible factor 1

Predicted to enable enzyme binding activity; ferrous iron binding activity; and peptidyl-proline 4-dioxygenase activity. Involved in several processes, including cellular iron ion homeostasis; regulation of angiogenesis; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within heart morphogenesis and labyrinthine layer development. Located in glutamatergic synapse. Is active in postsynaptic density. Is expressed in brain; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1). [provided by Alliance of Genome Resources, Apr 2022]