Slc8a3 - solute carrier family 8 (sodium/calcium exchanger), member 3

Enables calcium:sodium antiporter activity and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and nervous system development. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; modulation of excitatory postsynaptic potential; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including mitochondrial outer membrane; postsynaptic density; and sarcolemma. Is integral component of plasma membrane. Is expressed in several structures, including bone; brain; foregut; genitourinary system; and trachea. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Apr 2022]