Chrna5 - cholinergic receptor, nicotinic, alpha polypeptide 5

Predicted to enable acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within response to nicotine. Located in dopaminergic synapse. Part of acetylcholine-gated channel complex. Is expressed in gut; lung; nervous system; and thymus. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). [provided by Alliance of Genome Resources, Apr 2022]